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In clinical studies, approximately 13. Prolonged hemodialysis may be considered if clinically appropriate. It is not Order cheap Biaxin of brand Januvia Price renal insufficiency compared to normal healthy control subjects. In addition, the effects of renal insufficiency on sitagliptin pharmacokinetics in patients with brand Januvia Price 2 diabetes and mild or moderate renal insufficiency were assessed using population pharmacokinetic analyses. Because increases of this magnitude are not clinically relevant, dosage adjustment in patients with mild renal insufficiency is not necessary.

Plasma AUC levels of sitagliptin were increased approximately 2-fold and 4-fold in patients with moderate renal insufficiency and in patients with severe renal insufficiency, including patients with ESRD on hemodialysis, respectively.

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These differences are not considered to be clinically meaningful.

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